Product main information:
Protuct Name:Melanotan 2 MT II
Sequence: Ac-NLE-c[ASP-His-d-PHE-ARG-TRP-LYS]-NH2 Chemical Bridge Asp2-Lys7
Cas No.: 121062-08-6
Molecular Formula: C50H69N15O9
Molecular Weight: 1024.18
Purity (HPLC): 98.0%
Appearance: White powder
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: 10% of theoretical
Peptide Content (N%): >80.0%
Water Content(Karl Fischer): <8.0%
Acetate Content(HPIC): <10.0%
Specific Rotation (20/D): -55.0~-65.0(c=1 1%HAc)
package: (5mg or 10mg/vial,10vial/kit)
Packaging: Bubble/ aluminum foil bag/ box
Shipping Method:EMS,DHL,UPS,TNT or FEDEX
Delivery TIme: 1working day after receive the payment
Arrive Time:4-7 days
Payment Method: Western Union, MoneyGram, Bank Transfer and paypal.
Melanotan II also known as PT-141 was developed by researchers at the University of Arizona College of Medicine. Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (?-MSH), this hormone provides a therapeutic tan with the ability to lower the risk of skin cancer, (MSH) also plays an important role in regulating sexual arousal in men and women. Melanotan II has the additional effect of decreasing body fat mass. Melanotan II It is a cyclic lactyam analog of alpha-MSH with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.
Melanotan II is in a class of peptide hormone known as Melanocortins (MCs). Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals.
Melanotan II was first synthesized at the University of Arizona. Researches there knew that onc of the best defenses against skin cancer was melanin activated in the skin, a tan. They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body's natural pigmentary system to produce a protective tan prior to UV exposure. The body's naturally occuring hormone MSH causes melanogenesis, a process by which the skin's pigment cells (melanocytes) produce the skin's pigment (melanin). They tested to see if administering this endogenous hormone to the body directly could be an effective method to cause sunless tanning. What they found was that while it appeared to work, natural MSH had too short a half life in the body to be practical as a therapeutic drug. So they decided to find a more potent and stable alternative, one that would be more practical.
After synthesizing and screening hundreds of molecules, the researchers headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7] MSH, that was approimately 1,000 times more potent than the natural MSH. They dubbed this new peptide molecule, "Melanotan" (later Melanotan-1, now know as afamelanotide). They subsequently developed another analog, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2), which they called "Melanotan" Tanning Injections. The scientists hoped to use these peptides to combat melanoma by stimulating the body's natural pigmentary mechanism to create a tan without first needing exposure to harmful levels of UV radiation. This in turn, they hypothesized, could reduce the potential for skin damage that can eventually lead to skin cancer.
A pilot phase I clinical trial conducted on three males by the College of Medacine, Pharmacology Department, University of Arizona in Tuscon, Arizona pulished in 1996 reported that, "Melanotan" Tanning Injections has tanning activity in humans given only 5 low doses every other day by subcutaneous injection." The side effects reported were mild nausea and a "stretching and yawning complex" that correlated with spontaneous penile erections.
The Department of Pharmacology, University of Arizona College of Medacin published in 1998 that involved 10 men who suffered from psychogenic erectile dysfunction. Their trial concluded that, "Melanotan" Tanning Injections is a potent initiator of erections in men with pyschogenic erectile dydfunction and has manageable side effects at a dose of 0.025mg/kg.
A clinical study published in 2000 of 20 men with psychogenic and organic erectile dysfunction conducted at the Section of Urology of The University of Arizona College of Medacin concluded, "that Melanotan II Tanning Injections is a potent initiator of penile erection in men with ecrectile dysfunction.
CJC-1295 without DAC
CJC-1295 with DAC
HGH Fragment 176-191
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